🟩 Ruxotor 10 mg
Generic Name: Ruxolitinib Phosphate INN
Brand Name: Ruxotor
Manufacturer: Everest Pharmaceuticals Ltd.
Strength & Form: 10 mg | Film-coated tablets
Pack Size: 60 tablets
📌 Indications:
Ruxotor (Ruxolitinib) is indicated for the treatment of:
-
Myelofibrosis (MF): including primary myelofibrosis, post–polycythemia vera MF, and post–essential thrombocythemia MF.
-
Polycythemia Vera (PV): in patients resistant or intolerant to hydroxyurea.
-
Graft-versus-Host Disease (GVHD): in steroid-refractory acute and chronic GVHD.
💊 Pharmacology:
-
Ruxolitinib is a Janus-associated kinase (JAK1 and JAK2) inhibitor.
-
It works by reducing overactive JAK-STAT signaling, which is involved in abnormal blood cell production, inflammation, and immune system dysregulation.
-
By inhibiting JAK1/JAK2, Ruxotor decreases splenomegaly, alleviates disease-related symptoms (fever, night sweats, weight loss), and improves quality of life in MF and PV patients.
💉 Dosage & Administration:
-
Typical starting dose (MF/PV): 5–20 mg orally twice daily, based on platelet count.
-
GVHD: 5–10 mg twice daily (dose adjustments may be needed).
-
Doses should be individualized according to platelet counts, hemoglobin levels, and neutrophil counts.
-
Tablets should be swallowed whole, with or without food.
⚠️ Precautions & Warnings:
-
Monitor for cytopenias (anemia, thrombocytopenia, neutropenia).
-
Risk of serious infections (TB, herpes zoster, hepatitis B reactivation).
-
May increase the risk of skin cancers and non-melanoma malignancies.
-
Regular monitoring of complete blood counts (CBC) is essential.
❌ Contraindications:
-
Hypersensitivity to Ruxolitinib or formulation components.
-
Severe hepatic impairment (without close monitoring and dose adjustment).
🤰 Pregnancy & Lactation:
-
May cause fetal harm; avoid during pregnancy.
-
Breastfeeding is not recommended during treatment.
⚕️ Side Effects:
Common:
-
Anemia, thrombocytopenia, neutropenia
-
Headache, dizziness
-
Bruising
-
Increased liver enzymes
-
Weight gain
Serious:
-
Severe infections
-
Progressive multifocal leukoencephalopathy (PML)
-
Secondary malignancies
🧊 Storage Conditions:
-
Store below 30°C, in a dry place.
-
Protect from light and moisture.
-
Keep out of reach of children.
